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6-APB (6-(2-aminopropyl)benzofuran) is a synthetic compound that shares similarities with MDMA and MDA. It acts by releasing serotonin, dopamine, and norepinephrine in the brain, producing feelings of euphoria and increased energy. 6-APB (6-(2-aminopropyl)benzofuran) is a stimulant and entactogen that first appeared on the research chemical market around 2010. It is known for its euphoria and empathy-enhancing effects.  

Everything You Need to Know About 6-apb succinate (“Benzofury”)

6-APB, also known as Benzofury, is a synthetic stimulant and entactogen. It’s popular in recreational drug use for its mood-enhancing effects.

What is 6-APB?

Chemical Name: 6-(2-Aminopropyl)benzofuran
Molecular Formula: C11H13NO

6-APB is similar to MDMA and has effects like euphoria, increased sociability, and enhanced sensory perception. It is similar in structure to MDA, but differs in that the 3,4-methylenedioxyphenyl ring system has been replaced with a benzofuran ring. 6-APB is also the unsaturated benzofuran derivative of 6-APDB. It may appear as a tan grainy powder. While the drug never became particularly popular, it briefly entered the rave and underground clubbing scene in the UK before its sale and import were banned.

It falls under the category of research chemicals, sometimes called “legal highs.” Because 6-APB and other substituted benzofurans have not been explicitly outlawed in some countries, they are often technically legal, contributing to their popularity.

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Chemical Structure and Properties

6-APB is structurally related to MDA and MDMA, sharing a benzofuran ring structure.

Property Detail
IUPAC Name 6-(2-aminopropyl)benzofuran
Molecular Formula C11H13NO
Molecular Weight 175.23 g/mol
Chemical Structure

Synthesis of 6-APB

The synthesis involves multiple steps, starting with the reaction of 3-bromophenol and bromoacetaldehyde diethylacetal, followed by heating with polyphosphoric acid. The final product is separated into its structural isomers and converted to 6-APB.

Pharmacology

6-APB acts by releasing serotonin, which leads to mood elevation and euphoria. It also affects dopamine and norepinephrine to a lesser extent.

Neurotransmitter Effect
Serotonin Euphoria, mood enhancement
Dopamine Mild stimulant effects
Norepinephrine Increased alertness

Effects and Side Effects

Positive Effects

  • Euphoria
  • Increased sociability
  • Enhanced sensory perception

Negative Effects

  • Increased heart rate
  • Elevated body temperature
  • Risk of serotonin syndrome
Effect Description
Euphoria A powerful, pleasurable feeling often described as a warm, tingling sensation.
Increased Sociability Users often feel more outgoing and talkative.
Enhanced Sensory Perception Colors and sounds may appear more vivid and enjoyable.
Increased Heart Rate Can be uncomfortable and dangerous at high doses.
Elevated Body Temperature Users should be cautious of overheating and dehydration.
Risk of Serotonin Syndrome A potentially fatal condition if too much serotonin is released.

Dosage and Duration

6-APB is available in different forms: freebase, hydrochloride, and succinate. The freebase form is the most potent.

Dosage Guidelines

Form Threshold Light Common Strong Heavy
Freebase 10 mg 20-50 mg 50-80 mg 80-120 mg 120 mg +
Hydrochloride 15 mg 30-60 mg 60-90 mg 90-120 mg 120 mg +
Succinate 20 mg 40-80 mg 80-120 mg 120-160 mg 160 mg +

Duration of Effects

Stage Duration
Onset 30-60 minutes
Come Up 60-120 minutes
Peak 3-4 hours
Offset 2-3 hours
After Effects 6-48 hours

The legal status of 6-APB varies by country.

Country Legal Status
United States Schedule I (illegal)
Canada Not explicitly illegal, but may be controlled
United Kingdom Class B (illegal)
Australia Schedule 9 (illegal)