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Metonitazene is an opioid medication that was originally mentioned in 1957. It is a powerful agonist at the -opioid receptor and is 100 or more times stronger than morphine. Fentanyl and metonitazene both have effects that are analgesic, sedative, and euphoric. Metonitazene has not been used extensively in medicine. If the dosage is exceeded, respiratory depression, vomiting, and even death are serious side effects of metonitazene that can very quickly lead to dependence.