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What is Isotonitazene? | Isotonitazene for sale

Isotonitazene for sale, also known by its chemical name N,N-diethyl-2-[(4-methoxyphenyl)methyl]-5-nitro-1H-benzimidazole-1-ethanamine, is a synthetic opioid that belongs to the benzimidazole class of compounds. It was first synthesized in the 1970s by a team of researchers exploring the potential medical applications of benzimidazole derivatives. Isotonitazene exhibits potent analgesic properties, making it highly effective in relieving pain. Buy Isotonitazene online

History of Isotonitazene (CAS Number: 14188-81-9)

The history of Isotonitazene dates back to the 1970s when it was initially synthesized by pharmaceutical researchers. However, its potential medical applications were not fully explored at the time, and it remained largely unknown to the medical community. It wasn’t until recent years that Isotonitazene gained attention as a recreational drug and a dangerous substance of abuse.

N-desethyl isotonitazene, also known as NEI, is a derivative of isotonitazene. It is formed when isotonitazene is metabolized in the body. NEI is also a potent opioid and exhibits similar effects to isotonitazene. However, it is important to note that NEI has not been extensively studied and its long-term effects and safety profile are not well understood.

Isotonitazene for sale

Chemical Structure and Pharmacology

Isotonitazene has a complex chemical structure, consisting of a benzimidazole core with a nitro group and an ethylamine side chain. This unique structure contributes to its potent analgesic properties and high affinity for opioid receptors in the central nervous system. Isotonitazene acts primarily as a mu-opioid receptor agonist, producing powerful pain relief and sedation like protonitazene

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Appearance and Forms

  • Powder: Commonly found in the United States.
  • Tablets: Seen in Canada and some European countries.
  • Liquid: Identified in regions like Sweden and Germany.


Isotonitazene affects the central nervous system by binding to opioid receptors in the brain, leading to effects such as:

  • Euphoria
  • Relaxation
  • Respiratory depression

Side Effects

The side effects of Isotonitazene are similar to those of other opioids and include:

  • Drowsiness
  • Decreased heart rate
  • Slowed or stopped breathing
  • Addiction and dependence

Dangers and Risks

One of the most alarming aspects of Isotonitazene is its role in overdose deaths. The drug’s high potency means even a small amount can be lethal, especially when mixed with other substances like heroin or fentanyl. Overdose symptoms can include:

  • Bluish skin, lips, or fingertips
  • Unresponsiveness
  • Loss of consciousness
  • Respiratory failure


Treating an overdose of Isotonitazene often requires multiple doses of naloxone, a medication that can reverse opioid overdoses. However, due to the drug’s potency, it might need higher or repeated administrations compared to other opioids.

Legal Status and Regulation

As a relatively new synthetic opioid, Isotonitazene has not yet been subjected to comprehensive legal regulations in many jurisdictions. However, due to its potential for abuse and harm, some countries have taken proactive measures to control its distribution and use. In the United States, for example, Isotonitazene is classified as a Schedule I controlled substance, making its possession, distribution, and manufacture illegal.

 Isotonitazene in the Media

The emergence of Isotonitazene as a dangerous synthetic opioid has garnered significant media attention. News outlets have reported on the increasing number of overdoses and deaths related to Isotonitazene use, highlighting the urgent need for public awareness and intervention. The media plays a crucial role in disseminating information about the risks associated with Isotonitazene and raising awareness among the general population.

Treatment and Harm Reduction Strategies

The recommended treatment for isotonitazene addiction includes detoxification followed by behavioral therapy and counseling. During detoxification, individuals should receive medical monitoring and support to manage withdrawal symptoms safely. Behavioral treatments, such as cognitive-behavioral therapy (CBT) and contingency management, can help individuals overcome their addiction and maintain sobriety. Medications like methadone or buprenorphine may also be prescribed to reduce cravings during the early stages of recovery

Isotonitazene has been classified as a Schedule I drug under the Controlled Substances Act in the United States since 2020, indicating it has a high potential for abuse and no accepted medical use.

Locations Found

Isotonitazene has been detected in various U.S. states, including:

  • California
  • Illinois
  • Ohio
  • Wisconsin

It has also been reported in countries across Europe and other parts of the world.

For more detailed information, you can refer to sources like the DEAAddiction Resource, and BMJ for in-depth analysis and updates on Isotonitazene.

References: Isotonitazene for sale

  1. DEA. (n.d.). New, Dangerous Synthetic Opioid in D.C., Emerging in Tri-State Area. Retrieved from
  2. BMJ. (2021). The ‘new synthetic opioid’: Isotonitazene the secret killer? Retrieved from
  3. Addiction Resource. (n.d.). What Is Isotonitazene? Retrieved from