Image depicting the concept of flubromazolam half-life

Flubromazolam, also known as JYI-73, is a benzodiazepine derivative and a member of the triazolobenzodiazepine (TBZD) class [1]. It is reputed to be highly potent and has raised concerns due to its ability to produce strong sedation and amnesia even at oral doses as low as 0.5 mg [1]. One crucial aspect that users and researchers often seek to understand is the half-life of flubromazolam, as it directly affects the duration of its effects and the potential for prolonged toxicity [3]. In this article, we will delve into the topic of flubromazolam’s half-life and shed light on its implications for users.

Understanding Flubromazolam

Flubromazolam, a potent benzodiazepine derivative, belongs to the triazolobenzodiazepine class [6]. It exhibits anxiolytic, disinhibiting, sedative, muscle relaxant, and memory suppressing effects upon administration [6]. Due to its high potency, it is active in microgram quantities, making it essential for users to have a clear understanding of its half-life and duration of effects.

CAS 99593-25-6: What You Need to Know

CAS 99593-25-6 is the chemical abstract service (CAS) number assigned to flubromazolam. This unique identifier is used by scientists and researchers to refer to a specific chemical compound. It ensures accuracy and clarity when discussing the substance, especially in scientific literature and regulatory documents.


Property Value
Common Name Flubromazolam
CAS Number 612526-40-6
PubChem CID 21930924
ChemSpider 10684757
CompTox Dashboard (EPA) DTXSID40620266
Chemical and Physical Data Formula: C17H12BrFN4
Molar Mass 371.213 g·mol−1
3D Model (JSmol)
Duration Total: 12 – 18 hours
Onset: 30 – 60 minutes
After effects: 24 hours +
IUPAC Name 8-bromo-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine


The Importance of Half-Life in Benzodiazepines

The half-life of a drug refers to the time it takes for the concentration of the drug in the body to reduce by half [3]. Understanding the half-life of flubromazolam is crucial for users, as it helps determine the duration of its effects and the potential for accumulation or prolonged toxicity.

 Determining Flubromazolam’s Half-Life

In vitro studies of flubromazolam have shown a half-life of 182 minutes, indicating a relatively short duration [3]. However, it is essential to note that the half-life of a drug can vary among individuals due to factors such as metabolism, liver function, and other physiological variables.

Factors Influencing Half-Life

Several factors can influence the half-life of flubromazolam, including individual variations in metabolism, liver function, age, weight, and co-administration with other drugs [3]. For example, drug interactions with inhibitors or inducers of the cytochrome P450 system, specifically the 3A4/5 enzyme, may impact the metabolism and elimination of flubromazolam.

 Flubromazolam’s Metabolites and Prolonged Toxicity

The long half-life of flubromazolam, along with the production of active metabolites, can contribute to prolonged toxicity [4]. This means that even after the drug is no longer present in the body, the metabolites may continue to exert effects and pose potential risks.

Comparing Flubromazolam’s Half-Life with Other Benzodiazepines

While specific data on flubromazolam’s half-life is limited, comparisons can be drawn with other benzodiazepines. For instance, flubromazolam’s long half-life distinguishes it from benzodiazepines like lorazepam, which has a half-life of 10-12 hours [11]. The unique pharmacokinetics of flubromazolam contribute to its prolonged duration of action and potential for extended effects.

 Effects of Flubromazolam Half-Life on Users

The half-life of flubromazolam plays a significant role in the duration and intensity of its effects. Users should be aware that the long half-life of flubromazolam may lead to prolonged sedation, amnesia, and impaired cognitive and motor functions. It is important to consider the potential consequences and plan accordingly when using flubromazolam. Buy MXiPr

 Managing the Effects of Flubromazolam

To manage the effects of flubromazolam, users should adopt responsible use practices. Starting with a low dose and avoiding redosing before the drug has cleared the system can help minimize the risk of prolonged sedation or amnesia. Users should also create a safe environment, ensure proper support, and avoid operating machinery or driving until the effects have completely worn off.

Long-Term Effects and Withdrawal

Using flubromazolam over an extended period can lead to the development of tolerance, dependence, and potentially severe withdrawal symptoms upon discontinuation. The long half-life of flubromazolam can contribute to the duration and intensity of withdrawal symptoms, making it crucial for users to seek professional guidance when ceasing its use.

Image depicting the concept of flubromazolam half-life

Flubromazolam Half-Life: User Experiences and Reports

User experiences with flubromazolam’s half-life can vary. Some individuals report effects lasting for around 4-6 hours, while others note effects lasting for a longer duration [9]. These variations may be attributed to differences in metabolism, dosage, and individual responses to the drug.

 Safety Precautions and Responsible Use

To minimize the risks associated with flubromazolam, users should adhere to safety precautions and practice responsible use. This includes obtaining the substance from reputable sources, accurately measuring doses, avoiding excessive consumption, and being aware of potential drug interactions.

Comparing Flubromazolam with Other Benzodiazepines

Flubromazolam, with its unique characteristics and potency, differs from other benzodiazepines in several ways. While it shares similarities in its mechanism of action and therapeutic effects, its potency sets it apart. Smaller doses of flubromazolam can produce significant sedation and anxiolytic effects compared to other benzodiazepines. This potency makes it important to approach flubromazolam with caution and respect, ensuring responsible use under medical guidance. Rilmazafone Half-Life Explained: What You Need to Know

Etizolam: The Street Name and Its Popularity

Etizolam, also known by its street name “Etiz,” is a thienodiazepine compound that is chemically related to benzodiazepines. It has gained popularity in certain regions as a prescription medication for anxiety and insomnia, as well as for recreational use. Etizolam is known for its anxiolytic, sedative, and muscle-relaxing properties. However, it is crucial to note that the non-medical use of etizolam is not regulated or approved in many countries, including the United States.


Thienotriazolodiazepine is a class of compounds that includes flubromazolam and etizolam. These substances share similarities in their chemical structure and pharmacological effects. Thienotriazolodiazepines are known for their sedative, anxiolytic, and hypnotic properties, making them useful in the treatment of various conditions. However, their potent nature necessitates careful use and medical supervision to avoid adverse effects and addiction.

Flubromazolam Addiction and Withdrawal

As with other benzodiazepines, prolonged or excessive use of flubromazolam can lead to dependence and addiction. Abruptly stopping the drug or reducing the dosage without medical supervision can trigger withdrawal symptoms, including anxiety, insomnia, irritability, tremors, and seizures. It is crucial to seek professional help when discontinuing flubromazolam to ensure a safe and comfortable withdrawal process.


Understanding the half-life of flubromazolam is essential for users to gauge the duration and potential risks of its effects. While the specific half-life of flubromazolam may vary among individuals, it is generally characterized by a relatively short duration. However, the production of active metabolites and the potential for prolonged toxicity necessitate responsible use and careful consideration of its effects. By staying informed, practicing responsible use, and seeking professional help when needed, users can navigate the complexities surrounding flubromazolam’s half-life and make informed decisions regarding their well-being.


1. Is flubromazolam more potent than other benzodiazepines? Yes, flubromazolam is reputed to be highly potent compared to other designer benzodiazepines [1]. However, it is important to exercise caution and consider the potential risks associated with its use.

2. How long does flubromazolam stay in the body? The duration of flubromazolam in the body depends on various factors, including metabolism and individual characteristics. While the half-life is relatively short, the production of active metabolites may contribute to prolonged effects and toxicity.

3. Can flubromazolam lead to withdrawal symptoms? Yes, using flubromazolam over an extended period can result in tolerance, dependence, and potentially severe withdrawal symptoms upon discontinuation. Seeking professional help is advised for managing withdrawal from flubromazolam.

4. How can I safely use flubromazolam? To use flubromazolam safely, it is important to start with a low dose, avoid redosing before the drug has cleared the system, and create a safe environment. Responsible use practices, accurate measurement of doses, and awareness of potential drug interactions are also essential.

5. Where can I seek help for flubromazolam-related issues? If you or someone you know is facing challenges related to flubromazolam use, it is important to seek professional help. Medical and mental health professionals can provide guidance, support, and appropriate interventions to address the concerns effectively.

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