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What is JWH-018? JWH 018 powder is a synthetic cannabinoid. An organic chemist named John W. Huffman first made it in 2008. It gained popularity in 2009. German chemists found it then. It was a chemical in the popular synthetic cannabis blend Spice. Cannabinoid JWH 018 for sale

What is Jwh-018 synthetic cannabinoid?

JWH-018 is a synthetic cannabinoid whose chemical structure is based on that of both of the other two major cannabinoids used as precursors in making synthetic cannabinoid products. JWH-018 is slightly less potent than JWH-073. JWH-018 spray may have effects similar to those of other hallucinogenic synthetic cannabinoids and an onset of action that is similar to that of JWH-018.

JWH 018 is most often sold as a pill or liquid that is inserted into an inhaler.

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How to make homemade JWH-018

 

What is JWH-018?

Property Details
Common Names K2, Spice, Black Mamba, Brazilian Beet, Euphoria, BPAL
Formal Name 1-naphthalene(1-pentyl-1H-indol-3-yl)-methanone
Routes of Administration Smoked, Oral
Legal Status AU: S9 (Prohibited substance), CA: Schedule II, DE: Anlage II (Authorized trade only, not prescriptible), UK: Class B, US: Schedule I
IUPAC Name naphthalene-1-yl(1-pentyl-1H-indol-3-yl)methanone
CAS Number 209414-07-3
PubChem CID 10382701
ChemSpider 8558143
UNII G391998J57
ChEMBL ChEMBL561013
Formula C24H23NO
Molar Mass 341.454 g·mol−1
Solubility in Water Hydrophobic, n/a mg/mL (20 °C)
Purity ≥98%
SMILES CCCCCn1cc(C(=O)c2cccc3ccccc23)c2ccccc12
InChI Code InChI=1S/C24H23NO/c1-2-3-8-16-25-17-22(20-13-6-7-15-23(20)25)24(26)21-14-9-11-18-10-4-5-12-19(18)21/h4-7,9-15,17H,2-3,8,16H2,1H3
InChI Key JDNLPKCAXICMBW-UHFFFAOYSA-N

Effects of JWH-018

JWH-018 can produce effects similar to THC but is often much more potent. The effects can include both desired and adverse reactions.

Effect Description
Euphoria Feelings of happiness and relaxation
Altered Perception Changes in sight, sound, and time perception
Anxiety Increased feelings of anxiety and panic
Paranoia Intense paranoia and suspicious thoughts
Seizures Risk of seizures, especially at high doses
Psychosis Can trigger psychotic episodes

Risks and Dangers

Using JWH-018 comes with significant risks due to its potency and potential side effects.

Risk Details
Addiction Potential for psychological dependence
Withdrawal Severe withdrawal symptoms compared to cannabis
Cardiovascular Issues May cause heart problems, though not fully understood
Mental Health Can exacerbate existing mental health issues
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Street names for JWH 018

Chemicals such as Jwh-018, commonly referred to as “fake pot,” can be packaged under various names.

JWH-018 is sold as JWH-018 SPARY.

  • K2,
  • Spice,
  • Black Mamba,
  • Brazilian Beet,
  • Euphoria,
  • and BPAL.
  • Jawa

How to make JWH-018 at home

How to smoke JWH-018 powder

To smoke JWH-018 powder, you will first need to heat it to a liquid form. Once it is in liquid form, you can then use a syringe to inject it into a cigarette or vape cartridge. You can then smoke the cigarette or vape the cartridge as you would any other nicotine product.

Note that JWH-018 is a synthetic cannabinoid, so it will produce the same effects as other synthetic cannabinoids, such as Spice or K2. These effects can include relaxation, euphoria, and altered perception. JWH-018 is also reportedly more potent than other synthetic cannabinoids, so it is important to start with a low dose and increase it gradually if you are new to this drug.

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The legal status of JWH-018 varies by country and has changed over time due to health concerns.

Country Status
United States Schedule I Controlled Substance
United Kingdom Class B Drug
Australia Schedule 9 Prohibited Substance
Canada Schedule II: Controlled Substance
Germany Controlled under the Narcotics Act

Detection in Biological Fluids

JWH-018 can be detected in urine and blood, though specialized tests are required.

Test Type Description
Urine Test Detects parent drug and metabolites
Blood Test Measures concentrations in the blood

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JWH-018 is a powerful synthetic cannabinoid that can produce intense effects. While it was initially created for research, its use in recreational products has led to significant health concerns and legal restrictions. Understanding its properties and risks is crucial for informed use and safety.

Summary Table

Aspect Details
Chemical Name Naphthalen-1-yl(1-pentyl-1H-indol-3-yl)methanone
Effects Euphoria, altered perception, anxiety, seizures
Risks Addiction, withdrawal, cardiovascular issues, psychosis
Legal Status It is illegal in many countries
Detection Urine and blood tests

By understanding JWH-018, you can better appreciate the complexities and dangers of synthetic cannabinoids. Always stay informed and prioritize safety when dealing with such substances.

 What is JWH-018, and what are its street names?

JWH-018, chemically known as 1-pentyl-3-(1-naphthoyl)indole, is a synthetic cannabinoid designed to mimic THC, the psychoactive compound in cannabis. Marketed under names like “Spice” or “K2,” it’s often sold as “herbal incense” but packs a far more dangerous punch. Unlike natural cannabis, JWH-018 binds aggressively to the brain’s cannabinoid receptors, leading to unpredictable and severe side effects .


What does “JWH” stand for?

The abbreviation JWH refers to John W. Huffman, the organic chemist at Clemson University who first synthesized this compound in the 1990s while researching pain management therapies. Ironically, his work has been co-opted to create illicSpice.s like Spice.


 What are the acute side effects of JWH-018?

JWH-018’s potency as a full agonist at CB1 and CB2 receptors leads to intense physiological reactions:

  • Cardiovascular strain: Rapid heart rate, hypertension, or even life-threatening bradycardia
  • Neurological chaos: paranoia, hallucinations, and seizures .
  • Respiratory issues: labored breathing and tachypnea .

Animal studies reveal that even low doses can disrupt heart rhythms, with antidotes like atropine only partially reversing these effects.


How does JWH-018 appear on a drug screen?

Standard THC tests often miss JWH-018. Instead, specialized LC-MS/MS screenings are required to detect its metabolites, such as hydroxylated compounds in urine. A 2010 study identified monohydroxylated metabolites as the primary markers, with concentrations ranging from 6–50 μg/L in users 7 Elite athletes are particularly scrutinized under World Anti-Doping Agency protocols due to their performance-altering risks .


What is JWH-073, and where is it found?

JWH-073, a structural analog of JWH-018, is another synthetic cannabinoid often mixed into products like Forest Humus or post-ban Spice blends. Like JWH-018, it’s a full agonist at CB1 receptors but with slightly lower potency. After Germany banned JWH-018 in 2009, manufacturers substituted JWH-073 to skirt regulations.


How long do JWH-018’s effects last?

When inhaled, JWH-018 has a median half-life of 1.69 hours, but its metabolites linger for days. Hydroxylated compounds, particularly those glucuronide-conjugated, prolong detection windows in urine tests 67. Chronic use can lead to cumulative toxicity, with serum concentrations as low as 1–10 μg/L linked to fatal overdoses.


What are the long-term risks?

Repeated use rewires the brain, especially in adolescents. Studies in mice show:

  • Cognitive decline: impaired memory and sensory gating, akin to schizophrenia
  • Psychosis risk: microglial activation in the prefrontal cortex, reducing parvalbumin neurons critical for neural stability
  • Dependency: withdrawal symptoms surpass those of cannabis, including severe anxiety and agitation .

Is JWH-018 legal?

Globally, over 30 countries have banned JWH-018, including the U.S., EU nations, and Australia. However, manufacturers exploit legal loopholes by tweaking its chemical structure (e.g., shortening the alkyl chain) to create new, unregulated variants 611.

Country Ban Date Legal Status Notes
United States March 2011 Schedule I controlled substance
Germany January 2009 BtMG Anlage II
Australia September 2011 Schedule 9 prohibited

 Can JWH-018 cause death?

Yes. Case reports link JWH-018 to organ failure and cardiac arrest, even in young, healthy individuals. A 2011 fatality in South Carolina was attributed to “drug toxicity and organ failure” from JWH-018 use


What should you do if someone overdoses?

No FDA-approved antidote exists. Emergency protocols focus on managing symptoms:

  • Benzodiazepines for seizures.
  • Beta-blockers for heart rate stabilization .
    An immediate medical intervention is critical.

Final Takeaways
JWH-018 isn’t “safe high”—it’s a chemical gamble with irreversible consequences. From cardiac crises to lasting brain damage, its risks are stark. Stay informed, avoid synthetic blends, and seek help for dependency.

CTANeed help or more info? Reach out to addiction support networks like SAMHSA or consult a healthcare provider.


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