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What is Proscaline? Understanding its Effects and Uses

Proscaline  is a relatively new designer drug with hallucinogenic and psychedelic properties and structural and pharmacodynamic properties similar to drugs such as Mescaline, Isoproskaline, and Escaline. The unusual psychedelic stimulant phenethylamine, which is an analog of mescaline and has similar effects, has structural/pharmacological properties similar to those of its mescaline analogs such as isoproscaline, escaline, and allylescalin. Proskaline has structural, pharmacological, and chemical properties very similar to the psychedelic stimulants often used as designer drugs.

Information Value
Common Name Proscaline
Substitutive Name 4-propyloxy-3,5-dimethoxyphenethylamine
Class Membership Psychoactive class: Psychedelic
Chemical class: Phenethylamine
CAS Number 39201-78-0 check
ChemSpider 10439596
PubChem CID 15102790
CompTox Dashboard (EPA) DTXSID00192454
InChI InChI=1S/C13H21NO3/c1-4-7-17-13-11(15-2)
InChI InChI=1/C13H21NO3/c1-4-7-17-13-11(15-2)

Proscaline is a psychedelic and hallucinogenic drug that is used as an entheogen. Proscaline is a class of compounds known as phenethylamines and is the 4-propanedoxy homolog of mescaline. It is a 4-propyloxy analog of mescaline, which means that it has an additional carbon alkyloxy group, while escaline is a closely related mescaline analog.

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Proscaline is a psychedelic and hallucinogenic drug used by some as an entheogen. It is believed that its psychedelic effect stems from its effectiveness as a partial agonist of the 5-HT-2A receptor. Escalin (4-ethoxy homologist) and mescaline (proscaline-4-propoxy homologist) are themselves two to three times stronger than mescaline.

The effects of proscaline

The hallucinogenic potency of mescaline is increased by the methylation homologation of the 4-methoxy group, although it is not clear whether structural modifications on the activity of the drug in rodent models have a similar effect. Escalin is twice as effective in mice as mescaline, while prescaling is twice as effective. Subjective effects are similar to those of Mescaline, including open and closed eyes, visual and temporal distortions, improved introspection and conceptual thinking, euphoria, and ego loss.

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It has been reported to cause less visual effects, euphoria, and ego loss than mescaline. Mescaline has a lower logP (0.78) than the values for escalin (logP 1.11) and proscaline (logCp 1.70), which is close to the optimum value (Nichols and Dyer 1977; Nichols and Dyer 1977). A synthesis of proscamine was published by David E. Nichols in 1977 and appeared on the online market for research chemicals in the 2010s. JWH 210 Cannabinoid

What Happens When You Overdose On Proscaline?

The toxicity and long-term health effects of the use of recreational drugs are not reported in a scientific context and the exact toxic dosages are unknown. Proscaline is a 3,5-dimethoxy-4-propyloxyphenethylamine (substituted phenethylamine) with a phenyl ring bound to an amino group of the ethyl chain.

Precautions to take while using proscaline

To compare the behavioral effects of mescaline analogs, I used head twitches in mice. Homologation with the 4-alkoxy group had similar effects on efficacy in mice (HTR). In contrast, efficacy was increased by inducing homologations with 4-methoxy groups of mescaline (TMA-1) and TMA-2, but it had little or no effect on behavioral efficacy.

Proscaline (4-Propyloxy-3,5-di-Methoxy-Phenethylamine). Proskaline synthesis was published in 1977 by David E. Nichols. Correlation between the effectiveness of hallucinogens in mouse head twitches and their behavioral and subjective effects in other species.

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 Effects and Pharmacology

When administered, Proscaline induces modified mescaline-like hallucinogenic effects. Users report experiencing altered perceptions of reality, visual and auditory hallucinations, and enhanced sensory experiences. As with any psychedelic substance, the effects can vary depending on individual body weight, tolerance, metabolism, and personal sensitivity.

Threshold 15mg
Light 15-30mg
Common 30-40mg
Strong 40-60mg

Safety and Precautions

As with all psychedelic substances, responsible use is essential. Users should follow safety guidelines, start with lower doses, and avoid excessive consumption. Always verify dosage information from reliable sources

 Comparison with Other Psychedelics

Proscaline is unique among psychedelics due to its specific chemical structure and effects. Unlike some other substances, it is known for its longer duration, allowing users to explore their inner experiences more deeply

Popularity and Usage

The popularity of Proscaline has grown among psychonauts and researchers interested in studying its effects and potential therapeutic benefits. As with all research chemicals, its usage should be limited to scientific and academic purposes .


Proscaline, a member of the phenethylamine class, is a synthetic psychedelic that shares similarities with mescaline and escaline. Its unique effects and potential therapeutic benefits have attracted the interest of researchers and enthusiasts alike. As with all psychedelic substances, responsible use, and adherence to safety guidelines are paramount. More research is needed to fully understand Proscaline’s effects and its place in the realm of psychedelic compounds.


Can Proscaline be used as a recreational drug?

Proscaline is a research chemical and should not be used for recreational purposes. Its use should be limited to scientific research and academic investigations.

Is Proscaline addictive?

Proscaline is not believed to be physically addictive, but psychological dependence can develop with misuse. Avoid using it solely for entertainment purposes.

Are there any known long-term side effects of Proscaline use?

Long-term effects of Proscaline are not yet fully understood due to limited research. Users should practice responsible use and adhere to recommended dosages.

Is Proscaline legal worldwide?

The legal status of Proscaline varies by country and region. It is essential to research the specific laws in your location before acquiring or using Proscaline.

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